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    srsx-34 G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srsx-34
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein
    Primary source
    WormBase:WBGene00016093
    Locus tag
    CELE_C25E10.3
    See related
    AllianceGenome:WB:WBGene00016093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srsx-34 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (9035985..9040350)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein
    NP_001367564.1
    • Partially confirmed by transcript evidence
    NP_505341.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9035985..9040350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072940.6 → NP_505341.1  MFS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ09
      Conserved Domains (2) summary
      cl00339
      Location:49 → 90
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
      cl21472
      Location:36 → 229
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_001380720.1 → NP_001367564.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ10
      Conserved Domains (2) summary
      cd14964
      Location:9 → 34
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 269
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. NR_145827.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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