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    dhhc-4 DHHC-types zinc finger protein;Palmitoyltransferase;Zinc finger DHHC domain-containing protein 4 [ Caenorhabditis elegans ]

    Gene ID: 191420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhhc-4
    Official Full Name
    DHHC-types zinc finger protein;Palmitoyltransferase;Zinc finger DHHC domain-containing protein 4
    Primary source
    WormBase:WBGene00014075
    Locus tag
    CELE_ZK757.4
    See related
    AllianceGenome:WB:WBGene00014075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane and synaptic vesicle maturation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including enteric muscle; hypodermis; nervous system; rectal gland cell; and reproductive system. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15); ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2); and ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhhc-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (9863218..9867792, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DHHC-types zinc finger protein;Palmitoyltransferase;Zinc finger DHHC domain-containing protein 4
    NP_001023032.1
    • Partially confirmed by transcript evidence
    NP_001023033.1
    • Confirmed by transcript evidence
    NP_001122751.1
    • Partially confirmed by transcript evidence
    NP_001255038.1
    • Product from WormBase gene class dhhc;
      Confirmed by transcript evidence
    NP_001255039.1
    • Product from WormBase gene class dhhc;
      Confirmed by transcript evidence
    NP_001255040.1
    • Confirmed by transcript evidence
    NP_001255041.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class dhhc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9863218..9867792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268111.4 → NP_001255040.1  Palmitoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDL2
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 251
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_001129279.5 → NP_001122751.1  Palmitoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG19
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 272
      DHHC; DHHC palmitoyltransferase

    3. NM_001027861.6 → NP_001023032.1  Zinc finger DHHC domain-containing protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I0G4
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 272
      zf-DHHC; DHHC palmitoyltransferase

    4. NM_001027862.5 → NP_001023033.1  Palmitoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECT4
      Conserved Domains (1) summary
      pfam01529
      Location:131 → 274
      zf-DHHC; DHHC palmitoyltransferase

    5. NM_001268112.3 → NP_001255041.1  DHHC-types zinc finger protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255041.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBV7

    6. NM_001268109.3 → NP_001255038.1  DHHC-types zinc finger protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU67

    7. NM_001268110.3 → NP_001255039.1  DHHC-types zinc finger protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU68
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I0G4.1

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