efl-1 E2F/DP family winged-helix DNA-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: efl-1
Official Full Name: E2F/DP family winged-helix DNA-binding domain-containing protein
Primary source: WormBase:WBGene00001161
Locus tag: CELE_Y102A5C.18
See related: AllianceGenome:WB:WBGene00001161
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate carcinoma. Orthologous to several human genes including E2F4 (E2F transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See efl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (16958590..16965675, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F and HSF-1 directly regulate a gene network, including a specific subset of chaperones, to promote protein biogenesis and anabolic metabolism, which are essential in development.
Title: E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.
Efl-1 regulates organismal senescence by inhibiting daf-16.
Title: E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.
Efl-1/E2F and other SynMuv B genes negatively regulate a component of the anaphase-promoting complex or cyclosome (APC/C).
Title: Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components.
Title: Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).
dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death.
Title: DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y102A5C.18 (e-PCR)
- UniSTS:322445

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E2F/DP family winged-helix DNA-binding domain-containing protein

NP_507289.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16958590..16965675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074888.7 → NP_507289.1 E2F/DP family winged-helix DNA-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507289.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EF11

Conserved Domains (3) summary

cd14660
Location:152 → 187

E2F_DD; coiled coil [structural motif]

pfam02319
Location:67 → 131

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam16421
Location:157 → 254

E2F_CC-MB; E2F transcription factor CC-MB domain