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    sao-1 GYF domain-containing protein;Suppressor of aph-1 [ Caenorhabditis elegans ]

    Gene ID: 3565237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sao-1
    Official Full Name
    GYF domain-containing protein;Suppressor of aph-1
    Primary source
    WormBase:WBGene00011195
    Locus tag
    CELE_R10D12.14
    See related
    AllianceGenome:WB:WBGene00011195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables WD40-repeat domain binding activity. Involved in negative regulation of Notch signaling pathway and regulation of protein deneddylation. Located in cell cortex and cleavage furrow. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sao-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13963926..13965801)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine transferase subunit ALG13 Neighboring gene CCD97-like C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Glycoside hydrolase family 19 catalytic domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between DLC-1 and SAO-1 facilitates CED-4 translocation during apoptosis in the Caenorhabditis elegans germline. Zhang D, et al. Cell Death Discov, 2022 Nov 3. PMID 36323675, Free PMC Article
    2. Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans. Hale VA, et al. Genetics, 2012 Mar. PMID 22209900, Free PMC Article
    3. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    4. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    5. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables WD40-repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GYF domain-containing protein;Suppressor of aph-1
    NP_001041151.1
    • Confirmed by transcript evidence
    NP_001256550.1
    • Partially confirmed by transcript evidence
    NP_001256551.1
    • Confirmed by transcript evidence
    NP_001360561.1
    • Partially confirmed by transcript evidence
    NP_001360562.1
    • Confirmed by transcript evidence
    NP_001379456.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13963926..13965801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269622.3 → NP_001256551.1  Suppressor of aph-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256551.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRN1
      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues

    2. NM_001392643.1 → NP_001379456.1  Suppressor of aph-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues

    3. NM_001269621.3 → NP_001256550.1  Suppressor of aph-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRN1, C6KRN2, Q1ZXT3, Q1ZXT4
      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues

    4. NM_001047686.4 → NP_001041151.1  Suppressor of aph-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRN1
      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues

    5. NM_001373151.3 → NP_001360562.1  GYF domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVM9
      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues

    6. NM_001373150.2 → NP_001360561.1  GYF domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WV16
      Conserved Domains (1) summary
      smart00444
      Location:13 → 68
      GYF; Contains conserved Gly-Tyr-Phe residues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C6KRN1.1

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