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    twnk-1 SF4 helicase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    twnk-1
    Official Full Name
    SF4 helicase domain-containing protein
    Primary source
    WormBase:WBGene00018514
    Locus tag
    CELE_F46G11.1
    See related
    AllianceGenome:WB:WBGene00018514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' DNA helicase activity and single-stranded DNA binding activity. Predicted to be involved in mitochondrial DNA replication. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See twnk-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (5791215..5797343)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inner membrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine TWINKLE and mitochondrial ribosomal protein L43 genes are regulated by an evolutionary conserved bidirectional promoter. Meersseman C, et al. Gene, 2014 Mar 1. PMID 24361965
    2. ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Dai CY, et al. Nat Cell Biol, 2023 Aug. PMID 37460695
    3. Hypoxia-induced mitochondrial stress granules. Sun CL, et al. Cell Death Dis, 2023 Jul 19. PMID 37468471, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SF4 helicase domain-containing protein
    NP_001355545.1
    • Confirmed by transcript evidence
    NP_001368724.1
    • Partially confirmed by transcript evidence
    NP_001370999.1
    • Confirmed by transcript evidence
    NP_508973.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5791215..5797343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368518.5 → NP_001355545.1  SF4 helicase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6PCZ1
      Conserved Domains (1) summary
      cl38936
      Location:288 → 567
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_076572.6 → NP_508973.3  SF4 helicase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508973.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRT0
      Conserved Domains (1) summary
      cl38936
      Location:288 → 594
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001383588.2 → NP_001370999.1  SF4 helicase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NIH1
      Conserved Domains (1) summary
      cd01122
      Location:299 → 580
      Twinkle_C; C-terminal domain of Twinkle

    4. NM_001380982.1 → NP_001368724.1  SF4 helicase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6N6A0
      Conserved Domains (1) summary
      cd01122
      Location:299 → 598
      Twinkle_C; C-terminal domain of Twinkle
    Nucleotide Protein
    Heading Accession and Version

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