rpc-2 DNA-directed RNA polymerase subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpc-2
Official Full Name: DNA-directed RNA polymerase subunit beta
Primary source: WormBase:WBGene00017300
Locus tag: CELE_F09F7.3
See related: AllianceGenome:WB:WBGene00017300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpc-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (5557365..5564837)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09F7.3 (e-PCR)
- UniSTS:309625

F09F7.4 (e-PCR)
- UniSTS:309626

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase subunit beta

NP_498192.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5557365..5564837

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065791.8 → NP_498192.2 DNA-directed RNA polymerase subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498192.2

Status: REVIEWED

UniProtKB/TrEMBL

Q27492

Conserved Domains (4) summary

PRK08565
Location:28 → 1150

PRK08565; DNA-directed RNA polymerase subunit B; Provisional

cd00653
Location:41 → 1148

RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...

pfam04566
Location:552 → 613

RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4

pfam04567
Location:634 → 674

RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5