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    cof-2 Olfactomedin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cof-2
    Official Full Name
    Olfactomedin-like domain-containing protein
    Primary source
    WormBase:WBGene00000583
    Locus tag
    CELE_C48E7.5
    See related
    AllianceGenome:WB:WBGene00000583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to several human genes including GLDN (gliomedin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cof-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (6250475..6252876)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chondroitin sulfate proteoglycan 4 Neighboring gene ncRNA Neighboring gene Saposin B-type domain-containing protein Neighboring gene CCAAT/enhancer-binding protein homolog 2 Neighboring gene LiPid Depleted

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glaucoma studies in the eyeless worm: stress responsiveness and temporal expression of the Caenorhabditis elegans myocilin-like gene, cof-2. Williams TR, et al. Cell Mol Biol (Noisy-le-grand), 2004 Sep. PMID 15641163
    2. A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans. Loria PM, et al. J Neurosci, 2004 Mar 3. PMID 14999070, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Olfactomedin-like domain-containing protein
    NP_491804.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6250475..6252876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059403.5 → NP_491804.2  Olfactomedin-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491804.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBT7
      Conserved Domains (1) summary
      pfam02191
      Location:234 → 478
      OLF; Olfactomedin-like domain
    Nucleotide Protein
    Heading Accession and Version

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