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    ppfr-1 Serine/threonine-protein phosphatase 4 regulatory subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 172761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppfr-1
    Official Full Name
    Serine/threonine-protein phosphatase 4 regulatory subunit 1
    Primary source
    WormBase:WBGene00008878
    Locus tag
    CELE_F16A11.3
    See related
    AllianceGenome:WB:WBGene00008878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity and protein phosphatase activator activity. Involved in several processes, including establishment of mitotic spindle orientation; polar body extrusion after meiotic divisions; and regulation of spindle elongation. Located in cytoplasm. Is expressed in several structures, including intestine; neurons; pharynx; ventral nerve cord; and vulval muscle. Orthologous to several human genes including PPP4R1 (protein phosphatase 4 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ppfr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    26
    Sequence:
    Chromosome: I; NC_003279.8 (9364099..9389982, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Wsv419 Neighboring gene Serine/threonine-protein kinase dyf-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-splicing ligase RtcB homolog Neighboring gene RING finger and SPRY domain-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. Zárate-Potes A, et al. Dev Comp Immunol, 2021 Oct. PMID 34051205
    2. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Han X, et al. Genetics, 2009 Mar. PMID 19087961, Free PMC Article
    3. STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Lu T, et al. Genetics, 2022 May 5. PMID 35298637, Free PMC Article
    4. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPFR-1, a regulatory subunit of a trimeric protein phosphatase 4 complex, enhanced katanin MT-severing activity during C. elegans meiosis.
      Title: Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of meiotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 4 regulatory subunit 1
    NP_001021388.1
    • Confirmed by transcript evidence
    NP_001021389.1
    • Confirmed by transcript evidence
    NP_001021390.1
    • Confirmed by transcript evidence
    NP_001122456.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9364099..9389982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026218.5 → NP_001021389.1  Serine/threonine-protein phosphatase 4 regulatory subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021389.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED93
      Conserved Domains (1) summary
      sd00044
      Location:258 → 286
      HEAT; HEAT repeat [structural motif]

    2. NM_001026217.4 → NP_001021388.1  Serine/threonine-protein phosphatase 4 regulatory subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFI6
      Conserved Domains (1) summary
      sd00044
      Location:258 → 286
      HEAT; HEAT repeat [structural motif]

    3. NM_001128984.4 → NP_001122456.2  Serine/threonine-protein phosphatase 4 regulatory subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122456.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECH5, G5ED93, G5EFI6
      Conserved Domains (1) summary
      sd00044
      Location:330 → 358
      HEAT; HEAT repeat [structural motif]

    4. NM_001026219.6 → NP_001021390.1  Serine/threonine-protein phosphatase 4 regulatory subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN0
      Conserved Domains (1) summary
      sd00044
      Location:258 → 286
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECH5.1

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