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    wshc-5 WASH complex subunit strumpellin [ Caenorhabditis elegans ]

    Gene ID: 172306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wshc-5
    Official Full Name
    WASH complex subunit strumpellin
    Primary source
    WormBase:WBGene00020259
    Locus tag
    CELE_T05E7.3
    See related
    AllianceGenome:WB:WBGene00020259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in several processes, including actin filament polymerization; endosome fission; and regulation of actin nucleation. Predicted to be part of WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wshc-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (6188153..6192632)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Torsin-1B Neighboring gene pre-microRNA mir-4916 Neighboring gene GPI mannosyltransferase pigv-1 Neighboring gene DUF7027 domain-containing protein Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WASH complex subunit strumpellin
    NP_491784.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6188153..6192632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059383.6 → NP_491784.1  WASH complex subunit strumpellin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01858
      Conserved Domains (1) summary
      pfam10266
      Location:18 → 958
      Strumpellin; Hereditary spastic paraplegia protein strumpellin
    Nucleotide Protein
    Heading Accession and Version

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