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    dos-3 Delta and OSM-11-like [ Caenorhabditis elegans ]

    Gene ID: 186905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dos-3
    Official Full Name
    Delta and OSM-11-like
    Primary source
    WormBase:WBGene00019331
    Locus tag
    CELE_K02F3.8
    See related
    AllianceGenome:WB:WBGene00019331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dos-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (835751..839591, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor zip-2 Neighboring gene ncRNA Neighboring gene DUF148 domain-containing protein Neighboring gene Fatty Acid/Retinol binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells. Zhang Z, et al. Nat Commun, 2024 Jun 8. PMID 38851828, Free PMC Article
    2. Notch signaling inhibits axon regeneration. El Bejjani R, et al. Neuron, 2012 Jan 26. PMID 22284182, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
      Title: DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Delta and OSM-11-like
    NP_497271.3
    • Product from WormBase gene class dos;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      835751..839591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064870.8 → NP_497271.3  Delta and OSM-11-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497271.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2MZA5
    Nucleotide Protein
    Heading Accession and Version

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