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    otpl-2 Otopetrin-2 [ Caenorhabditis elegans ]

    Gene ID: 183919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    otpl-2
    Official Full Name
    Otopetrin-2
    Primary source
    WormBase:WBGene00017034
    Locus tag
    CELE_D1065.1
    See related
    AllianceGenome:WB:WBGene00017034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in neurons and pharynx. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See otpl-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (4073755..4077573)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene G protein-coupled receptor;Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, et al. BMC Evol Biol, 2008 Feb 6. PMID 18254951, Free PMC Article
    2. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article
    3. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, et al. Hum Mol Genet, 2003 Apr 1. PMID 12651873
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Otopetrin-2
    NP_001309627.1
    • Partially confirmed by transcript evidence
    NP_001309628.1
    • Confirmed by transcript evidence
    NP_001309629.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4073755..4077573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322547.4 → NP_001309627.1  Otopetrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCH9
      Conserved Domains (1) summary
      pfam03189
      Location:149 → 538
      Otopetrin; Otopetrin

    2. NM_001322548.3 → NP_001309628.1  Otopetrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD93
      Conserved Domains (1) summary
      pfam03189
      Location:120 → 509
      Otopetrin; Otopetrin

    3. NM_001322549.3 → NP_001309629.1  Otopetrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBM4
      Conserved Domains (1) summary
      pfam03189
      Location:9 → 65
      Otopetrin; Otopetrin
    Nucleotide Protein
    Heading Accession and Version

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