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    dyc-1 Dystrophin-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 181515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyc-1
    Official Full Name
    Dystrophin-like protein 1
    Primary source
    WormBase:WBGene00001116
    Locus tag
    CELE_C33G3.1
    See related
    AllianceGenome:WB:WBGene00001116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of muscle. Involved in several processes, including muscle cell cellular homeostasis; regulation of egg-laying behavior; and sarcomere organization. Located in axon and striated muscle dense body. Part of dystrophin-associated glycoprotein complex. Is expressed in SDQ; body wall musculature; head; intestinal cell; and muscle cell. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (14049535..14063930)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans. Gieseler K, et al. Curr Biol, 2000 Sep 21. PMID 10996789
    2. Muscular dystrophy: the worm turns to genetic disease. Chamberlain JS, et al. Curr Biol, 2000 Nov 2. PMID 11084353
    3. The dystrophin-associated protein complex maintains muscle excitability by regulating Ca(2+)-dependent K(+) (BK) channel localization. Sancar F, et al. J Biol Chem, 2011 Sep 23. PMID 21795674, Free PMC Article
    4. DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1. Lecroisey C, et al. Mol Biol Cell, 2008 Mar. PMID 18094057, Free PMC Article
    5. Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Zhao G, et al. Genome Res, 2007 Mar. PMID 17284674, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein zyxin.
      Title: DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nitric-oxide synthase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitric-oxide synthase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dystrophin-associated glycoprotein complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dystrophin-like protein 1
    NP_001024439.1
    • Confirmed by transcript evidence
    NP_741925.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14049535..14063930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029268.6 → NP_001024439.1  Dystrophin-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8STF6, Q93325, Q9XZQ6
      Conserved Domains (3) summary
      TIGR01628
      Location:305 → 465
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd01270
      Location:6 → 185
      PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain
      pfam03154
      Location:210 → 392
      Atrophin-1; Atrophin-1 family

    2. NM_171796.6 → NP_741925.2  Dystrophin-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741925.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8STF6
      Conserved Domains (3) summary
      pfam03153
      Location:173 → 357
      TFIIA; Transcription factor IIA, alpha/beta subunit
      cl17171
      Location:17 → 91
      PH-like; Pleckstrin homology-like domain
      cl23720
      Location:345 → 425
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8STF6.1

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