vps-36 Vacuolar protein-sorting-associated protein 36 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-36
Official Full Name: Vacuolar protein-sorting-associated protein 36
Primary source: WormBase:WBGene00008919
Locus tag: CELE_F17C11.8
See related: AllianceGenome:WB:WBGene00008919
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in endosome. Predicted to be part of ESCRT II complex. Predicted to be active in late endosome membrane. Is expressed in body wall musculature; nervous system; non-striated muscle; and reproductive system. Orthologous to human VPS36 (vacuolar protein sorting 36 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-36 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (10958931..10960669, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the data in this study present here the first direct evidence that ESCRT-II components VPS-36, VPS-22 and VPS-25 share a specific sarcoplasmic reticulum sub-cellular localization in C. elegans muscle cells and are involved in sarcoplasmic reticulum shaping.
Title: The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F17C11.8 (e-PCR)
- UniSTS:307502

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vacuolar protein-sorting-associated protein 36

NP_505798.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10958931..10960669 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073397.8 → NP_505798.2 Vacuolar protein-sorting-associated protein 36 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505798.2

Status: REVIEWED

UniProtKB/TrEMBL

Q19519

Conserved Domains (2) summary

pfam04157
Location:152 → 368

EAP30; EAP30/Vps36 family

pfam11605
Location:2 → 88

Vps36_ESCRT-II; Vacuolar protein sorting protein 36 Vps36