brd-1 BRCA1-associated RING domain protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: brd-1
Official Full Name: BRCA1-associated RING domain protein 1
Primary source: WormBase:WBGene00000265
Locus tag: CELE_K04C2.4
See related: AllianceGenome:WB:WBGene00000265
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See brd-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (6885207..6889504, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
Title: Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
Title: PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
BRCA1-BARD1 Regulates Axon Regeneration in Concert with the Gqalpha-DAG Signaling Network.
Title: BRCA1-BARD1 Regulates Axon Regeneration in Concert with the Gqα-DAG Signaling Network.
Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
Title: Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
Title: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
the C. elegans homologs of the BRCA1/BARD1 tumor suppressor genes, brc-1/brd-1, were identified as mediators of the anti-apoptotic effect but dispensable for lifespan extension upon mitochondrial stress.
Title: BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans.
the synthetic sterility upon BRCA1/BARD1 and H3K9me2 loss is directly linked to the DNA damage provoked by unscheduled satellite repeat transcription.
Title: Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.
Data suggest that BRC-1/BRD-1 can both promote and antagonize genome stability depending on whether homologous recombination is initiated during DNA double-strand break repair or during replication stalling.
Title: Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
Ce-BRC-1 and Ce-BRD-1 share a role in C. elegans DNA repair processes.
Title: BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04C2.4 (e-PCR)
- UniSTS:311402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K6-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-BARD1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-BARD1 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BRCA1-associated RING domain protein 1

NP_498498.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6885207..6889504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066097.9 → NP_498498.3 BRCA1-associated RING domain protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498498.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21209

Conserved Domains (4) summary

cd00204
Location:348 → 449

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:352 → 444

Ank_2; Ankyrin repeats (3 copies)

pfam14634
Location:17 → 66

zf-RING_5; zinc-RING finger domain

sd00045
Location:347 → 377

ANK; ANK repeat [structural motif]