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    hst-2 Heparan sulfate 2-O-sulfotransferase hst-2 [ Caenorhabditis elegans ]

    Gene ID: 181309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hst-2
    Official Full Name
    Heparan sulfate 2-O-sulfotransferase hst-2
    Primary source
    WormBase:WBGene00002029
    Locus tag
    CELE_C34F6.4
    See related
    AllianceGenome:WB:WBGene00002029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heparan sulfate 2-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; regulation of axon guidance; and regulation of cell migration. Predicted to be located in Golgi apparatus. Is expressed in several structures, including P6.pa; P6.paa; P6.pap; hermaphrodite distal tip cell; and somatic nervous system. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hst-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (11204103..11207155, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene MARVEL domain-containing protein Neighboring gene NR LBD domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Kinnunen T, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15671174, Free PMC Article
    2. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Dierker T, et al. Sci Rep, 2016 Oct 5. PMID 27703236, Free PMC Article
    3. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Turnbull J, et al. Biochem Soc Trans, 2003 Apr. PMID 12653634
    4. Genetic analysis of the heparan modification network in Caenorhabditis elegans. Townley RA, et al. J Biol Chem, 2011 May 13. PMID 21454666, Free PMC Article
    5. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, et al. Nat Methods, 2012 Apr 1. PMID 22466794, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulfotransferase activity in C. elegans is critical for normal heparan sulfate functions in controlling cell migration.
      Title: Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heparan sulfate 2-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 2-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparan sulfate 2-O-sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heparan sulfate 2-O-sulfotransferase hst-2
    NP_509871.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11204103..11207155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077470.6 → NP_509871.2  Heparan sulfate 2-O-sulfotransferase hst-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509871.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17645
      Conserved Domains (1) summary
      cl22970
      Location:42 → 293
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17645.2

    Gene LinkOut

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