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    del-3 DEgenerin Like [ Caenorhabditis elegans ]

    Gene ID: 184955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    del-3
    Official Full Name
    DEgenerin Like
    Primary source
    WormBase:WBGene00009144
    Locus tag
    CELE_F26A3.6
    See related
    AllianceGenome:WB:WBGene00009144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See del-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (7670155..7672714, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine-phosphatase Neighboring gene DDE_Tnp_1_7 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Golgin-84

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors. Rhoades JL, et al. Cell, 2019 Jan 10. PMID 30580965, Free PMC Article
    2. High-fidelity encoding of mechanostimuli by tactile food-sensing neurons requires an ensemble of ion channels. Fok A, et al. Cell Rep, 2023 May 30. PMID 37119137, Free PMC Article
    3. A serotonergic circuit regulates aversive associative learning under mitochondrial stress in C. elegans. Chiang YC, et al. Proc Natl Acad Sci U S A, 2022 Mar 15. PMID 35254908, Free PMC Article
    4. Serotonin and dopamine modulate aging in response to food odor and availability. Miller HA, et al. Nat Commun, 2022 Jun 7. PMID 35672307, Free PMC Article
    5. Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. Kaulich E, et al. J Physiol, 2023 May. PMID 36200489, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEgenerin Like
    NP_492135.1
    • Product from WormBase gene class del;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7670155..7672714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059734.4 → NP_492135.1  DEgenerin Like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93597
      Conserved Domains (1) summary
      pfam00858
      Location:17 → 226
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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