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    bli-5 Kunitz-type protein bli-5 [ Caenorhabditis elegans ]

    Gene ID: 185812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bli-5
    Official Full Name
    Kunitz-type protein bli-5
    Primary source
    WormBase:WBGene00000255
    Locus tag
    CELE_F45G2.5
    See related
    AllianceGenome:WB:WBGene00000255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables serine-type endopeptidase activity. A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; protein catabolic process; and vulval development. Is expressed in excretory cell; excretory duct; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bli-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (13427640..13429768, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein Neighboring gene ncRNA Neighboring gene Exonuclease 1 Neighboring gene Coatomer subunit epsilon Neighboring gene TNF Receptor Associated Factor (TRAF) homolog Neighboring gene COMM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes. Stepek G, et al. Mol Biochem Parasitol, 2010 Jan. PMID 19716386
    2. Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. Page AP, et al. Int J Parasitol, 2006 May 31. PMID 16500660
    3. Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Ch'ng Q, et al. Genetics, 2003 Aug. PMID 12930745, Free PMC Article
    4. Most ultraviolet irradiation induced mutations in the nematode Caenorhabditis elegans are chromosomal rearrangements. Stewart HI, et al. Mutat Res, 1991 Jul. PMID 2067542
    5. The genetic analysis of a reciprocal translocation, eT1(III; V), in Caenorhabditis elegans. Rosenbluth RE, et al. Genetics, 1981 Nov-Dec. PMID 6953041, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BLI-5 plays a functionally conserved role in cuticle formation in a C. elegans and nematodes.
      Title: The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of collagen and cuticulin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kunitz-type protein bli-5
    NP_499772.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13427640..13429768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067371.3 → NP_499772.1  Kunitz-type protein bli-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62247
      Conserved Domains (1) summary
      cl00101
      Location:134 → 184
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62247.1

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