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    eri-5 Protein kinase domain-containing protein;Tudor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eri-5
    Official Full Name
    Protein kinase domain-containing protein;Tudor domain-containing protein
    Primary source
    WormBase:WBGene00021419
    Locus tag
    CELE_Y38F2AR.1
    See related
    AllianceGenome:WB:WBGene00021419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity and protein-macromolecule adaptor activity. Involved in siRNA processing. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eri-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (2390821..2396263)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Translocon-associated protein subunit gamma Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene 5-oxoprolinase;Hydantoinase B/oxoprolinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A truncated form of dicer tilts the balance of RNA interference pathways. Sawh AN, et al. Cell Rep, 2013 Aug 15. PMID 23933256
    2. Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants. Zhuang JJ, et al. Genetics, 2011 May. PMID 21385728, Free PMC Article
    3. Meiotic H3K9me2 distribution is influenced by the ALG-3 and ALG-4 pathway and by poly(U) polymerase activity. Li Y, et al. MicroPubl Biol, 2021. PMID 34549171, Free PMC Article
    4. GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in Caenorhabditis elegans. Almeida MV, et al. EMBO J, 2018 Jun 15. PMID 29769402, Free PMC Article
    5. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Thivierge C, et al. Nat Struct Mol Biol, 2011 Dec 18. PMID 22179787, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;Tudor domain-containing protein
    NP_001368292.1
    • Confirmed by transcript evidence
    NP_500199.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2390821..2396263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067798.6 → NP_500199.2  Tudor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500199.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XS0
      Conserved Domains (2) summary
      cd04508
      Location:382 → 415
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:30 → 136
      TUDOR; Tudor domain

    2. NM_001380092.1 → NP_001368292.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMJ7
      Conserved Domains (1) summary
      cl02573
      Location:9 → 46
      Tudor_SF; Tudor domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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