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    K08D12.3 CCHC-type domain-containing protein;CCHC-type zinc finger nucleic acid binding protein [ Caenorhabditis elegans ]

    Gene ID: 176979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    K08D12.3
    Official Full Name
    CCHC-type domain-containing protein;CCHC-type zinc finger nucleic acid binding protein
    Primary source
    WormBase:WBGene00019537
    Locus tag
    CELE_K08D12.3
    See related
    AllianceGenome:WB:WBGene00019537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity; single-stranded RNA binding activity; and translation regulator activity. Predicted to be involved in positive regulation of cytoplasmic translation. Predicted to be active in cytoplasm. Is expressed in body wall musculature; intestine; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including ZCCHC13 (zinc finger CCHC-type containing 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See K08D12.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (1710265..1711127)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C6 domain-containing protein Neighboring gene Proteasome subunit beta Neighboring gene Protein XRP2 Neighboring gene Ascaris suum EPICuticlin protein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCHC-type domain-containing protein;CCHC-type zinc finger nucleic acid binding protein
    NP_001367954.1
    • Confirmed by transcript evidence
    NP_741323.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1710265..1711127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171273.7 → NP_741323.1  CCHC-type zinc finger nucleic acid binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q966I7
      Conserved Domains (1) summary
      PTZ00368
      Location:1 → 148
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    2. NM_001380057.1 → NP_001367954.1  CCHC-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXU9
      Conserved Domains (1) summary
      PTZ00368
      Location:1 → 21
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    Nucleotide Protein
    Heading Accession and Version

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