ric-8 Chaperone ric-8;Synembryn;Synembryn-A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ric-8
Official Full Name: Chaperone ric-8;Synembryn;Synembryn-A
Primary source: WormBase:WBGene00004367
Locus tag: CELE_Y69A2AR.2
See related: AllianceGenome:WB:WBGene00004367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Is expressed in germ line and nervous system. Orthologous to several human genes including RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ric-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (2642977..2650111)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons.
Title: The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons.
Genetic epistasis experiments show that activator of G protein signaling (AGS-3) and guanine nucleotide exchange factor RIC-8 act during food deprivation in a mutually dependent fashion to activate G protein Galpha(o).
Title: AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.
Data suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division.
Title: RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
Analysis of a ric-8 mutant suggests that it is required to maintain both the G alpha(q) vesicle priming pathway and the neuronal G alpha(s) pathway in a functional state.
Title: Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network.
ric-8 (synembryn) paralysis can be rescued by neuronal G alpha(s) pathway activation.
Title: Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.
requirement toward GPA-16 is distinct from the known function of RIC-8 in enabling interaction between Galpha proteins and GPR-1/2
Title: Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
RIC-8 directly modulates Galpha activity and that Galpha-GTP is the signaling molecule regulating spindle positioning in the early embryo
Title: Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y69A2A_2326.b (e-PCR)
- UniSTS:324112

Y69A2A_7025.c (e-PCR)
- UniSTS:324199

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein kinase C signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in aster	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Chaperone ric-8;Synembryn;Synembryn-A

NP_001023561.1

Confirmed by transcript evidence

NP_001294606.1

Confirmed by transcript evidence

NP_001380145.1

Confirmed by transcript evidence

NP_001421841.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2642977..2650111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392268.1 → NP_001380145.1 Synembryn-A [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PF95

Conserved Domains (1) summary

pfam10165
Location:29 → 240

Ric8; Guanine nucleotide exchange factor synembryn
NM_001028390.5 → NP_001023561.1 Chaperone ric-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023561.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86DD4, Q9GSX9

Conserved Domains (1) summary

pfam10165
Location:66 → 538

Ric8; Guanine nucleotide exchange factor synembryn
NM_001434912.1 → NP_001421841.1 Chaperone ric-8 [Caenorhabditis elegans]

Status: REVIEWED
NM_001307677.4 → NP_001294606.1 Synembryn [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294606.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PS45

Conserved Domains (1) summary

pfam10165
Location:66 → 192

Ric8; Guanine nucleotide exchange factor synembryn