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    atg-5 Autophagy-related protein 5 [ Caenorhabditis elegans ]

    Gene ID: 171735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atg-5
    Official Full Name
    Autophagy-related protein 5
    Primary source
    WormBase:WBGene00022152
    Locus tag
    CELE_Y71G12B.12
    See related
    AllianceGenome:WB:WBGene00022152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to Atg8-family ligase activity. Involved in autophagosome assembly and regulation of autophagy. Predicted to be located in cytoplasm and membrane. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in autophagosome; phagophore; and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atg-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (1709587..1715564)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Sm domain-containing protein Neighboring gene FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ATG-5 mutants associated with ataxia. Yugeta A, et al. MicroPubl Biol, 2023. PMID 37334197, Free PMC Article
    2. Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. Alexander-Floyd J, et al. BMC Biol, 2020 Feb 24. PMID 32093691, Free PMC Article
    3. Autophagy in C. elegans. Meléndez A, et al. WormBook, 2009 Aug 24. PMID 19705512
    4. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
    5. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Wu F, et al. Mol Cell, 2015 Dec 17. PMID 26687600

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to Atg8-family ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related protein 5
    NP_001293440.1
    • Confirmed by transcript evidence
    NP_490885.3
    • Confirmed by transcript evidence
    NP_871858.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1709587..1715564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058484.9 → NP_490885.3  Autophagy-related protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490885.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3V5I7, Q3V5I8, W6RR39
      Conserved Domains (1) summary
      pfam04106
      Location:79 → 271
      APG5; Autophagy protein Apg5

    2. NM_001306511.5 → NP_001293440.1  Autophagy-related protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RR39
      Conserved Domains (1) summary
      pfam04106
      Location:79 → 269
      APG5; Autophagy protein Apg5

    3. NM_182058.5 → NP_871858.2  Autophagy-related protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871858.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3V5I8
      Conserved Domains (1) summary
      pfam04106
      Location:79 → 158
      APG5; Autophagy protein Apg5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V5I7.2

    Gene LinkOut

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