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    athp-2 Bromodomain adjacent to zinc finger domain protein 1A [ Caenorhabditis elegans ]

    Gene ID: 173769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    athp-2
    Official Full Name
    Bromodomain adjacent to zinc finger domain protein 1A
    Primary source
    WormBase:WBGene00019217
    Locus tag
    CELE_H20J04.2
    See related
    AllianceGenome:WB:WBGene00019217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in positive regulation of DNA replication; regulation of DNA-templated transcription; and regulation of heterochromatin formation. Predicted to be located in chromatin and nucleus. Predicted to be part of ACF complex and CHRAC. Predicted to be active in nuclear chromosome. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See athp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (4340182..4350987)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNA helicase Neighboring gene Alcohol dehydrogenase transcription factor myb/sant-like protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene Serpentine Receptor, class Z Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Dang W, et al. Cell Metab, 2014 Jun 3. PMID 24814484, Free PMC Article
    2. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Andersen EC, et al. Development, 2006 Jul. PMID 16774993
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ACF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bromodomain adjacent to zinc finger domain protein 1A
    NP_494767.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4340182..4350987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062366.6 → NP_494767.2  Bromodomain adjacent to zinc finger domain protein 1A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5L9
      Conserved Domains (6) summary
      smart00297
      Location:1306 → 1409
      BROMO; bromo domain
      smart00249
      Location:1100 → 1144
      PHD; PHD zinc finger
      smart00571
      Location:457 → 524
      DDT; domain in different transcription and chromosome remodeling factors
      pfam10537
      Location:23 → 123
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:629 → 671
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:795 → 897
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    Nucleotide Protein
    Heading Accession and Version

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