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    gfi-2 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gfi-2
    Official Full Name
    ANK_REP_REGION domain-containing protein
    Primary source
    WormBase:WBGene00001582
    Locus tag
    CELE_K02A11.1
    See related
    AllianceGenome:WB:WBGene00001582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be active in cytoplasm. Orthologous to human PPP1R16A (protein phosphatase 1 regulatory subunit 16A) and PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gfi-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9737816..9744146)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPOR domain-containing protein Neighboring gene Endoribonuclease endu-1 Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
    2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein
    NP_001366793.1
    • Confirmed by transcript evidence
    NP_001366991.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9737816..9744146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381135.1 → NP_001366991.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZS1
      Conserved Domains (3) summary
      PHA03095
      Location:69 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:61 → 87
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:53 → 153
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001381136.3 → NP_001366793.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90902
      Conserved Domains (3) summary
      PHA03095
      Location:69 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:61 → 87
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:53 → 153
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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