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    saps-1 Serine/threonine-protein phosphatase 6 regulatory subunit [ Caenorhabditis elegans ]

    Gene ID: 174725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    saps-1
    Official Full Name
    Serine/threonine-protein phosphatase 6 regulatory subunit
    Primary source
    WormBase:WBGene00008166
    Locus tag
    CELE_C47G2.5
    See related
    AllianceGenome:WB:WBGene00008166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein phosphatase binding activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Orthologous to several human genes including PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See saps-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (11297688..11301260)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTP-binding protein Neighboring gene Transmembrane protein 201 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells. Kotak S, et al. J Cell Sci, 2016 Aug 1. PMID 27335426, Free PMC Article
    2. Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Afshar K, et al. Development, 2010 Jan. PMID 20040490, Free PMC Article
    3. The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. Rivard RS, et al. PLoS One, 2020. PMID 33315870, Free PMC Article
    4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in first cell cycle pseudocleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 6 regulatory subunit
    NP_001122596.1
    • Confirmed by transcript evidence
    NP_001122597.1
    • Confirmed by transcript evidence
    NP_496414.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11297688..11301260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129124.5 → NP_001122596.1  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5Z2S4
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 508
      SAPS; SIT4 phosphatase-associated protein

    2. NM_064013.7 → NP_496414.2  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496414.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18696
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 508
      SAPS; SIT4 phosphatase-associated protein

    3. NM_001129125.3 → NP_001122597.1  Serine/threonine-protein phosphatase 6 regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5Z2S4, B2D6K9, Q18696
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 510
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2D6K9.1

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