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    unc-11 Phosphatidylinositol-binding clathrin assembly protein unc-11 [ Caenorhabditis elegans ]

    Gene ID: 171952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-11
    Official Full Name
    Phosphatidylinositol-binding clathrin assembly protein unc-11
    Primary source
    WormBase:WBGene00006751
    Locus tag
    CELE_C32E8.10
    See related
    AllianceGenome:WB:WBGene00006751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including endocytosis; necroptotic process; and protein localization to postsynaptic membrane. Located in clathrin-coated pit and presynaptic membrane. Is expressed in several structures, including epithelial cell; excretory gland cell; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (3798396..3805739, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SSD domain-containing protein Neighboring gene Ethylmalonyl-CoA decarboxylase Neighboring gene RING-type domain-containing protein Neighboring gene E3 ubiquitin-protein ligase ubr-1 Neighboring gene Nsp1_C domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Creation of a functional unc-11/PICALM GFP knock-in by CRISPR. Gallegos M, et al. MicroPubl Biol, 2021 Apr 28. PMID 33937722, Free PMC Article
    2. UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles. Nonet ML, et al. Mol Biol Cell, 1999 Jul. PMID 10397769, Free PMC Article
    3. Born again at the synapse: a new function for the anaphase promoting complex/cyclosome. Zarnescu DC, et al. Dev Cell, 2004 Dec. PMID 15572119
    4. Mutations in the ligand-binding and pore domains control exit of glutamate receptors from the endoplasmic reticulum in C. elegans. Grunwald ME, et al. Neuropharmacology, 2003 Nov. PMID 14529715
    5. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Burbea M, et al. Neuron, 2002 Jul 3. PMID 12123612

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of receptor localization to synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidylinositol-binding clathrin assembly protein unc-11
    NP_001021014.1
    • Confirmed by transcript evidence
    NP_001021016.1
    • Confirmed by transcript evidence
    NP_001361960.1
    • Confirmed by transcript evidence
    NP_001361961.1
    • Confirmed by transcript evidence
    NP_001361962.1
    • Confirmed by transcript evidence
    NP_001379757.1
    • Confirmed by transcript evidence
    NP_491227.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3798396..3805739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058826.3 → NP_491227.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q72, Q95Q73, Q95Q74, Q95Q75, Q9UA04, Q9UA05, Q9XZI6, Q9XZI7, Q9XZI8, Q9XZI9
      Conserved Domains (1) summary
      cl02544
      Location:37 → 299
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

    2. NM_001375250.2 → NP_001361962.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PHA03247
      Location:395 → 533
      PHA03247; large tegument protein UL36; Provisional
      cd16985
      Location:37 → 154
      ANTH_N_AP180; ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) subfamily

    3. NM_001025843.4 → NP_001021014.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZI6
      Conserved Domains (1) summary
      cl02544
      Location:37 → 299
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

    4. NM_001375251.4 → NP_001361960.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PRK07764
      Location:391 → 512
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16985
      Location:37 → 154
      ANTH_N_AP180; ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) subfamily

    5. NM_001375252.3 → NP_001361961.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam15822
      Location:392 → 588
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      cd16985
      Location:37 → 154
      ANTH_N_AP180; ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) subfamily

    6. NM_001025845.4 → NP_001021016.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZI6
      Conserved Domains (1) summary
      cl02544
      Location:37 → 299
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

    7. NM_001393277.1 → NP_001379757.1  Phosphatidylinositol-binding clathrin assembly protein unc-11 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZI6.1

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