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    jhdm-1 JmjC domain-containing histone demethylation protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jhdm-1
    Official Full Name
    JmjC domain-containing histone demethylation protein 1
    Primary source
    WormBase:WBGene00020821
    Locus tag
    CELE_T26A5.5
    See related
    AllianceGenome:WB:WBGene00020821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone demethylase activity and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See jhdm-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (6454483..6460014)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene UDENN domain-containing protein Neighboring gene Histone-lysine N-methyltransferase set-1;SET domain-containing protein Neighboring gene ncRNA Neighboring gene Chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene DNA polymerase epsilon subunit 3 Neighboring gene Dynein light chain 1, cytoplasmic

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants. Croft JC, et al. MicroPubl Biol, 2023. PMID 36793895, Free PMC Article
    2. Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans. Lee TW, et al. Elife, 2019 Dec 9. PMID 31815663, Free PMC Article
    3. The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Maures TJ, et al. Aging Cell, 2011 Dec. PMID 21834846, Free PMC Article
    4. An aging program at the systems level? Han JD. Birth Defects Res C Embryo Today, 2012 Jun. PMID 22692892
    5. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Hayes GD, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381276

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JmjC domain-containing histone demethylation protein 1
    NP_001299886.1
    • Confirmed by transcript evidence
    NP_498418.3
    • Confirmed by transcript evidence
    NP_498419.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6454483..6460014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066017.9 → NP_498418.3  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q98, Q95Q99
      Conserved Domains (2) summary
      PHA03193
      Location:1051 → 1102
      PHA03193; tegument protein VP11/12; Provisional
      cl21464
      Location:222 → 321
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_066018.10 → NP_498419.3  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q98
      Conserved Domains (1) summary
      cl21464
      Location:222 → 321
      cupin_like; Conserved domain found in cupin and related proteins

    3. NM_001312957.3 → NP_001299886.1  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUW2
      Conserved Domains (1) summary
      PHA03193
      Location:465 → 516
      PHA03193; tegument protein VP11/12; Provisional
    Nucleotide Protein
    Heading Accession and Version

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