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    sahd-1 Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [ Caenorhabditis elegans ]

    Gene ID: 173937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sahd-1
    Official Full Name
    Deoxynucleoside triphosphate triphosphohydrolase sahd-1
    Primary source
    WormBase:WBGene00022673
    Locus tag
    CELE_ZK177.8
    See related
    AllianceGenome:WB:WBGene00022673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables dGTPase activity; deoxynucleoside triphosphate hydrolase activity; and protein homodimerization activity. Involved in dGTP catabolic process. Predicted to be located in chromosome. Predicted to be active in nucleus. Is expressed in several structures, including excretory cell; hypodermis; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sahd-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (5509022..5514945, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein fzy-1 Neighboring gene putative cytochrome P450 CYP44 Neighboring gene Protein npp-24 Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog. Maehigashi T, et al. J Biol Chem, 2023 Sep. PMID 37567474, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dGTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dGTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxynucleoside triphosphate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dGTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dGTP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deoxyribonucleotide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Deoxynucleoside triphosphate triphosphohydrolase sahd-1
    NP_001412556.1
    • Confirmed by transcript evidence
    NP_001412557.1
    • Partially confirmed by transcript evidence
    NP_001412558.1
    • Confirmed by transcript evidence
    NP_495054.1
    • Confirmed by transcript evidence
    NP_495055.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5509022..5514945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062653.4 → NP_495054.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09374, Q95PX5
      Conserved Domains (1) summary
      cd00077
      Location:90 → 284
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    2. NM_062654.6 → NP_495055.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09374
      Conserved Domains (1) summary
      cd00077
      Location:56 → 250
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    3. NM_001425627.1 → NP_001412556.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

      Status: REVIEWED

    4. NM_001425628.1 → NP_001412557.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

      Status: REVIEWED

    5. NM_001425629.1 → NP_001412558.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09374.2

    Gene LinkOut

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