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    hdl-1 putative aromatic-L-amino-acid decarboxylase [ Caenorhabditis elegans ]

    Gene ID: 178129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hdl-1
    Official Full Name
    putative aromatic-L-amino-acid decarboxylase
    Primary source
    WormBase:WBGene00001839
    Locus tag
    CELE_ZK829.2
    See related
    AllianceGenome:WB:WBGene00001839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxy-lyase activity. Predicted to be involved in amino acid metabolic process; carboxylic acid metabolic process; and dopamine biosynthetic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hdl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (11946066..11949817, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sodium-dependent multivitamin transporter Neighboring gene DeHydrogenases, Short chain Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Putative T-box protein 36 Neighboring gene Glutamate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans. Marra MA, et al. Mol Gen Genet, 1993 Jan. PMID 8382340
    2. Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis. Hare EE, et al. BMC Evol Biol, 2004 Aug 2. PMID 15287963, Free PMC Article
    3. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5-hydroxy-L-tryptophan decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-dopa decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aromatic-L-amino-acid decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catecholamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative aromatic-L-amino-acid decarboxylase
    NP_502265.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11946066..11949817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069864.5 → NP_502265.2  putative aromatic-L-amino-acid decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502265.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34751, Q23619
      Conserved Domains (1) summary
      pfam00282
      Location:377 → 746
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34751.3

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