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    herc-1 HECT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    herc-1
    Official Full Name
    HECT domain-containing protein
    Primary source
    WormBase:WBGene00021685
    Locus tag
    CELE_Y48G8AL.1
    See related
    AllianceGenome:WB:WBGene00021685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to several human genes including HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See herc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (1211485..1254719)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Regulator of nonsense transcripts 1 Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase Neighboring gene FIP (Fungus-Induced Protein) Related;Fungus-induced protein 1 Neighboring gene Uncharacterized protein Neighboring gene TLC domain-containing protein Neighboring gene ncRNA Neighboring gene nucleoside-diphosphate kinase Neighboring gene CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HECT domain-containing protein
    NP_001293432.1
    • Confirmed by transcript evidence
    NP_001293433.1
    • Confirmed by transcript evidence
    NP_001293434.1
    • Confirmed by transcript evidence
    NP_001293435.1
    • Confirmed by transcript evidence
    NP_490834.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1211485..1254719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058433.6 → NP_490834.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL11
      Conserved Domains (2) summary
      COG5184
      Location:2 → 359
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:667 → 1016
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. NM_001306503.3 → NP_001293432.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY72
      Conserved Domains (1) summary
      cd00078
      Location:336 → 685
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. NM_001306504.3 → NP_001293433.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RS03
      Conserved Domains (1) summary
      cd00078
      Location:291 → 640
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. NM_001306505.3 → NP_001293434.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RTM2
      Conserved Domains (1) summary
      cd00078
      Location:152 → 501
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    5. NM_001306506.3 → NP_001293435.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBJ0
      Conserved Domains (1) summary
      cl27008
      Location:2 → 210
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
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