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    ncx-1 Calx-beta domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncx-1
    Official Full Name
    Calx-beta domain-containing protein
    Primary source
    WormBase:WBGene00003566
    Locus tag
    CELE_Y113G7A.4
    See related
    AllianceGenome:WB:WBGene00003566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in AIYL and AIYR. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1) and SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncx-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (20105633..20120673, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase Neighboring gene Protein transport protein SEC23 Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer's Disease. Zheng Z, et al. Oxid Med Cell Longev, 2022. PMID 36600949, Free PMC Article
    2. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calx-beta domain-containing protein
    NP_001041182.1
    • Confirmed by transcript evidence
    NP_001041183.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20105633..20120673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047717.7 → NP_001041182.1  Calx-beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF08
      Conserved Domains (5) summary
      smart00237
      Location:511 → 600
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:44 → 880
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:706 → 871
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:388 → 478
      Calx-beta; Calx-beta domain
      pfam16494
      Location:283 → 370
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    2. NM_001047718.6 → NP_001041183.1  Calx-beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RPT9
      Conserved Domains (4) summary
      smart00237
      Location:511 → 600
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      pfam01699
      Location:706 → 795
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:388 → 478
      Calx-beta; Calx-beta domain
      pfam16494
      Location:283 → 370
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
    Nucleotide Protein
    Heading Accession and Version

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