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    nhr-28 Nuclear hormone receptor family member nhr-28 [ Caenorhabditis elegans ]

    Gene ID: 181705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-28
    Official Full Name
    Nuclear hormone receptor family member nhr-28
    Primary source
    WormBase:WBGene00003624
    Locus tag
    CELE_C11G6.4
    See related
    AllianceGenome:WB:WBGene00003624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in body wall; head; hypodermis; intestine; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-28 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (16354976..16359650)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
    2. Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. Robinson-Rechavi M, et al. J Mol Evol, 2005 May. PMID 15983867
    3. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Arda HE, et al. Mol Syst Biol, 2010 May 11. PMID 20461074, Free PMC Article
    4. An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. Vergani-Junior CA, et al. Nat Commun, 2024 Apr 9. PMID 38594249, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-28
    NP_001024388.1
    • Confirmed by transcript evidence
    NP_001024389.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16354976..16359650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029217.7 → NP_001024388.1  Nuclear hormone receptor family member nhr-28 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17905, Q17906, Q5FC68, Q5VKU0, Q9GTI2, Q9GTI3
      Conserved Domains (2) summary
      smart00399
      Location:7 → 76
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:168 → 345
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001029218.7 → NP_001024389.1  Nuclear hormone receptor family member nhr-28 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024389.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17905
      Conserved Domains (2) summary
      smart00430
      Location:110 → 287
      HOLI; Ligand binding domain of hormone receptors
      cl02596
      Location:2 → 25
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17905.3

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