ldb-1 LIM domain-binding protein 1;LIM interaction domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ldb-1
Official Full Name: LIM domain-binding protein 1;LIM interaction domain-containing protein
Primary source: WormBase:WBGene00002261
Locus tag: CELE_F58A3.1
See related: AllianceGenome:WB:WBGene00002261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and LIM domain binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of vulval development; and regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including egg-laying apparatus; gonad; head neurons; ray neurons; and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ldb-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (11028917..11040612)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A3.1 (e-PCR)
- UniSTS:317495

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables LIM domain binding	IEA Inferred from Electronic Annotation more info
enables LIM domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIM domain-binding protein 1;LIM interaction domain-containing protein

NP_001366942.1

Partially confirmed by transcript evidence

NP_001379181.1

Confirmed by transcript evidence

NP_509845.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11028917..11040612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381099.1 → NP_001366942.1 LIM interaction domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O02518, O02599, Q93803, Q93807, Q9U3E2

Conserved Domains (3) summary

TIGR01628
Location:468 → 601

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

pfam01803
Location:102 → 316

LIM_bind; LIM-domain binding protein

pfam17916
Location:415 → 443

LID; LIM interaction domain (LID)
NM_077444.6 → NP_509845.1 LIM domain-binding protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509845.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4H8

Conserved Domains (3) summary

TIGR01628
Location:417 → 550

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

pfam01803
Location:51 → 277

LIM_bind; LIM-domain binding protein

pfam17916
Location:364 → 392

LID; LIM interaction domain (LID)
NM_001392840.1 → NP_001379181.1 LIM domain-binding protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEL0, Q8I4H8, Q8IU51

Conserved Domains (3) summary

TIGR01628
Location:431 → 564

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

pfam01803
Location:65 → 279

LIM_bind; LIM-domain binding protein

pfam17916
Location:378 → 406

LID; LIM interaction domain (LID)