rep-1 Rab proteins geranylgeranyltransferase component A 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: rep-1
Official Full Name: Rab proteins geranylgeranyltransferase component A 1
Primary source: WormBase:WBGene00022051
Locus tag: CELE_Y67D2.1
See related: AllianceGenome:WB:WBGene00022051
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity and Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in alimentary muscle; body wall musculature; hypodermis; and neurons. Human ortholog(s) of this gene implicated in asthma and choroideremia. Orthologous to human CHM (CHM Rab escort protein) and CHML (CHM like Rab escort protein). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

REP-1 functions are required in specific Rab pathways and in specific tissues, and that some Rab proteins are functionally prenylated without REP-1.
Title: Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Rab GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein geranylgeranylation	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_001022928.1

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