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    ptr-4 SSD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptr-4
    Official Full Name
    SSD domain-containing protein
    Primary source
    WormBase:WBGene00004219
    Locus tag
    CELE_C45B2.7
    See related
    AllianceGenome:WB:WBGene00004219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in endocytosis and molting cycle. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle membrane and plasma membrane. Is expressed in cuticular ala; epithelial cell; rectum; and vulva. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptr-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (6060758..6065986, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene phospholipase A2 Neighboring gene glutamine synthetase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix. Cohen JD, et al. Genetics, 2021 Nov 5. PMID 34740248, Free PMC Article
    2. BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans. Hyun M, et al. Genetics, 2016 Aug. PMID 27334271, Free PMC Article
    3. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
    4. Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan. Brinkmann V, et al. Aging (Albany NY), 2020 Dec 13. PMID 33349622, Free PMC Article
    5. Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects. Brinkmann V, et al. Antioxidants (Basel), 2022 Mar 23. PMID 35453298, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix.
      Title: The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SSD domain-containing protein
    NP_509013.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6060758..6065986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076612.8 → NP_509013.2  SSD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509013.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95YD0
      Conserved Domains (1) summary
      cl25655
      Location:137 → 938
      Patched; Patched family
    Nucleotide Protein
    Heading Accession and Version

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