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    Y43F8B.2 GSKIP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y43F8B.2
    Official Full Name
    GSKIP domain-containing protein
    Primary source
    WormBase:WBGene00012813
    Locus tag
    CELE_Y43F8B.2
    See related
    AllianceGenome:WB:WBGene00012813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinase regulator activity and protein kinase A binding activity. Involved in innate immune response. Located in striated muscle dense body. Is expressed in several structures, including nerve ring; tail hypodermis; and ventral nerve cord. Orthologous to human GSKIP (GSK3B interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y43F8B.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (19519938..19533110, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein;Titin;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    GSKIP domain-containing protein
    NP_001123045.1
    • Confirmed by transcript evidence
    NP_001256875.1
    • Confirmed by transcript evidence
    NP_001256876.1
    • Confirmed by transcript evidence
    NP_001256877.1
    • Confirmed by transcript evidence
    NP_001379035.1
    • Confirmed by transcript evidence
    NP_507796.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19519938..19533110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392701.1 → NP_001379035.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWX6
      Conserved Domains (1) summary
      pfam05303
      Location:83 → 186
      DUF727; Protein of unknown function (DUF727)

    2. NM_075395.5 → NP_507796.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWX7
      Conserved Domains (1) summary
      pfam05303
      Location:156 → 259
      DUF727; Protein of unknown function (DUF727)

    3. NM_001269946.4 → NP_001256875.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTN9
      Conserved Domains (1) summary
      pfam05303
      Location:135 → 238
      DUF727; Protein of unknown function (DUF727)

    4. NM_001129573.4 → NP_001123045.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1V8J2
      Conserved Domains (1) summary
      pfam05303
      Location:49 → 152
      DUF727; Protein of unknown function (DUF727)

    5. NM_001269947.3 → NP_001256876.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP0
      Conserved Domains (1) summary
      pfam05303
      Location:26 → 129
      DUF727; Protein of unknown function (DUF727)

    6. NM_001269948.3 → NP_001256877.1  GSKIP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP1
      Conserved Domains (1) summary
      pfam05303
      Location:1 → 81
      DUF727; Protein of unknown function (DUF727)
    Nucleotide Protein
    Heading Accession and Version

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