let-721 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-721
Official Full Name: Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Primary source: WormBase:WBGene00002855
Locus tag: CELE_C05D11.12
See related: AllianceGenome:WB:WBGene00002855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable electron-transferring-flavoprotein dehydrogenase activity. Predicted to be involved in electron transport chain. Located in mitochondrion. Is expressed in several structures, including excretory cell; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-721 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (6444693..6446907, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

find that LET-721 is a mitochondrially expressed protein that is under complex transcriptional controls.
Title: Characterizing the transcriptional regulation of let-721, a Caenorhabditis elegans homolog of human electron flavoprotein dehydrogenase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D11.12 (e-PCR)
- UniSTS:308939

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron-transferring-flavoprotein dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron-transferring-flavoprotein dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

NP_001379625.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6444693..6446907 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392123.1 → NP_001379625.1 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q11190

Conserved Domains (2) summary

COG0644
Location:48 → 508

FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]

pfam05187
Location:491 → 594

ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S