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    meg-3 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 180510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    meg-3
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00001569
    Locus tag
    CELE_F52D2.4
    See related
    AllianceGenome:WB:WBGene00001569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including P granule assembly; embryo development; and germ cell proliferation. Located in P granule. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See meg-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (1986469..1989607, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins. Lee CS, et al. Elife, 2020 Jan 24. PMID 31975687, Free PMC Article
    2. Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. Smith J, et al. Elife, 2016 Dec 3. PMID 27914198, Free PMC Article
    3. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Putnam A, et al. Nat Struct Mol Biol, 2019 Mar. PMID 30833787, Free PMC Article
    4. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. Seydoux G. J Mol Biol, 2018 Nov 2. PMID 30096346, Free PMC Article
    5. Protein-based condensation mechanisms drive the assembly of RNA-rich P granules. Schmidt H, et al. Elife, 2021 Jun 9. PMID 34106046, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_508367.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1986469..1989607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075966.6 → NP_508367.1  Uncharacterized protein CELE_F52D2.4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXM1
    Nucleotide Protein
    Heading Accession and Version

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