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    rad-50 DNA repair protein rad-50;Zinc-hook domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad-50
    Official Full Name
    DNA repair protein rad-50;Zinc-hook domain-containing protein
    Primary source
    WormBase:WBGene00004296
    Locus tag
    CELE_T04H1.4
    See related
    AllianceGenome:WB:WBGene00004296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Predicted to be involved in chromosome organization and double-strand break repair. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Predicted to be active in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rad-50 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (12245646..12251246)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Tr-type G domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene G patch domain-containing protein 11 Neighboring gene LRP X(cross)-hybridizing

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans. Baudrimont A, et al. PLoS One, 2011. PMID 21957461, Free PMC Article
    2. Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline. Reichman R, et al. Genetics, 2018 Apr. PMID 29472245, Free PMC Article
    3. The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. Rosu S, et al. PLoS Genet, 2013. PMID 23950729, Free PMC Article
    4. Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Girard C, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686104, Free PMC Article
    5. Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair. Hartsuiker E, et al. EMBO J, 2001 Dec 3. PMID 11726502, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein rad-50;Zinc-hook domain-containing protein
    NP_001122999.1
    • Confirmed by transcript evidence
    NP_506070.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12245646..12251246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129527.4 → NP_001122999.1  Zinc-hook domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYU5
      Conserved Domains (1) summary
      TIGR00606
      Location:16 → 1307
      rad50

    2. NM_073669.9 → NP_506070.1  DNA repair protein rad-50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44199, Q22177
      Conserved Domains (3) summary
      TIGR00606
      Location:2 → 1293
      rad50; rad50
      cd03240
      Location:1157 → 1279
      ABC_Rad50; ATP-binding cassette domain of Rad50
      pfam04423
      Location:646 → 694
      Rad50_zn_hook; Rad50 zinc hook motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44199.1

    Gene LinkOut

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