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    inpp-1 Inositol polyphosphate-related phosphatase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inpp-1
    Official Full Name
    Inositol polyphosphate-related phosphatase domain-containing protein
    Primary source
    WormBase:WBGene00012016
    Locus tag
    CELE_T25B9.10
    See related
    AllianceGenome:WB:WBGene00012016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and phosphatidylinositol-3-phosphate biosynthetic process. Located in cytoplasm. Is expressed in neurons. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inpp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (10770218..10773911, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene 6-phosphogluconate dehydrogenase, decarboxylating Neighboring gene Sugar transporter SWEET1 Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Circuit for Gradient Climbing in C. elegans Chemotaxis. Larsch J, et al. Cell Rep, 2015 Sep 22. PMID 26365196, Free PMC Article
    2. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables inositol trisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inositol polyphosphate-related phosphatase domain-containing protein
    NP_001255510.1
    • Confirmed by transcript evidence
    NP_001255511.1
    • Confirmed by transcript evidence
    NP_001294074.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10770218..10773911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307145.2 → NP_001294074.1  Inositol polyphosphate-related phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTE2
      Conserved Domains (1) summary
      smart00128
      Location:102 → 396
      IPPc; Inositol polyphosphate phosphatase, catalytic domain homologues

    2. NM_001268582.2 → NP_001255511.1  Inositol polyphosphate-related phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGN9
      Conserved Domains (1) summary
      smart00128
      Location:105 → 399
      IPPc; Inositol polyphosphate phosphatase, catalytic domain homologues

    3. NM_001268581.2 → NP_001255510.1  Inositol polyphosphate-related phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBY9
      Conserved Domains (1) summary
      smart00128
      Location:91 → 385
      IPPc; Inositol polyphosphate phosphatase, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version

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