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    F53H4.6 DNA repair and recombination protein RAD54-like [ Caenorhabditis elegans ]

    Gene ID: 181672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F53H4.6
    Official Full Name
    DNA repair and recombination protein RAD54-like
    Primary source
    WormBase:WBGene00010011
    Locus tag
    CELE_F53H4.6
    See related
    AllianceGenome:WB:WBGene00010011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP-dependent chromatin remodeler activity. Predicted to be involved in transcription-coupled nucleotide-excision repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F53H4.6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (15851951..15860606, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Acyl-coenzyme A oxidase Neighboring gene Stress-associated endoplasmic reticulum protein 2 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1 Neighboring gene DUF19 domain-containing protein Neighboring gene DNA repair and recombination protein RAD54-like Neighboring gene Mab-21 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair and recombination protein RAD54-like
    NP_001359661.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15851951..15860606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373603.4 → NP_001359661.1  DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86D18
      Conserved Domains (2) summary
      COG0553
      Location:195 → 654
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:195 → 381
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein
    Heading Accession and Version

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