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    trp-2 Transient receptor ion channel domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 192056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trp-2
    Official Full Name
    Transient receptor ion channel domain-containing protein
    Primary source
    WormBase:WBGene00006615
    Locus tag
    CELE_R06B10.4
    See related
    AllianceGenome:WB:WBGene00006615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to several human genes including TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trp-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (991881..1001931)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Rab-GAP TBC domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High concentrations of the anthelmintic diethylcarbamazine paralyze C. elegans independently of TRP-2. Datta R, et al. MicroPubl Biol, 2022. PMID 35622518, Free PMC Article
    2. A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels. Yeon J, et al. PLoS Biol, 2018 Jun. PMID 29883446, Free PMC Article
    3. Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi. Verma S, et al. Commun Biol, 2020 Jul 28. PMID 32724078, Free PMC Article
    4. Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans. Todd PA, et al. Sci Rep, 2016 Jul 20. PMID 27435667, Free PMC Article
    5. Function and regulation of TRP family channels in C. elegans. Xiao R, et al. Pflugers Arch, 2009 Sep. PMID 19421772, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Transient receptor ion channel domain-containing protein
    NP_001022703.1
    • Confirmed by transcript evidence
    NP_497311.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      991881..1001931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064910.9 → NP_497311.2  Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497311.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE02
      Conserved Domains (4) summary
      cd00204
      Location:37 → 163
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:34 → 785
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:177 → 236
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:69 → 96
      ANK; ANK repeat [structural motif]

    2. NM_001027532.5 → NP_001022703.1  Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I6Y9
      Conserved Domains (4) summary
      cd00204
      Location:37 → 163
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:34 → 757
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:177 → 236
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:69 → 96
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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