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    dop-4 Dopamine receptor 4 [ Caenorhabditis elegans ]

    Gene ID: 183715, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dop-4
    Official Full Name
    Dopamine receptor 4
    Primary source
    WormBase:WBGene00016872
    Locus tag
    CELE_C52B11.3
    See related
    AllianceGenome:WB:WBGene00016872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables dopamine neurotransmitter receptor activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in intestine; nervous system; rectum; and vulva. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Orthologous to several human genes including ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See dop-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (1295253..1298830)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NF-kappa-B inhibitor-interacting Ras-like protein 1 Neighboring gene pseudo Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling. Ezcurra M, et al. EMBO J, 2011 Mar 16. PMID 21304491, Free PMC Article
    2. Alcohol disinhibition of behaviors in C. elegans. Topper SM, et al. PLoS One, 2014. PMID 24681782, Free PMC Article
    3. Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. Cao X, et al. Curr Biol, 2016 Sep 12. PMID 27524480, Free PMC Article
    4. Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor. Ardiel EL, et al. Learn Mem, 2016 Oct. PMID 27634141, Free PMC Article
    5. Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans. Jiang Y, et al. BMC Biol, 2022 Mar 23. PMID 35317792, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study established a high-throughput learning assay that used real-time computer vision software for behavioral tracking and optogenetics for stimulation of the C. elegans polymodal nociceptor, ASH. Food and dopamine signaling slowed habituation downstream from ASH excitation via D1-like dopamine receptor, DOP-4. Assay allows for large-scale genetic and drug screens investigating mechanisms of nociception modulation.
      Title: Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor.
    2. DOP-4 shows high sequence homology with D1-like dopamine receptors unique to invertebrates, distinct from mammalian D1-like dopamine receptors. Reporter gene assay showed that DOP-4 stimulates cAMP accumulation in response to dopamine stimulation.
      Title: Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dopamine receptor 4
    NP_508238.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1295253..1298830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075837.5 → NP_508238.2  Dopamine receptor 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508238.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18775
      Conserved Domains (2) summary
      pfam00001
      Location:59 → 463
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:53 → 245
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18775.2

    Gene LinkOut

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