Y57G11C.22 PRKCA-binding protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y57G11C.22
Official Full Name: PRKCA-binding protein
Primary source: WormBase:WBGene00013317
Locus tag: CELE_Y57G11C.22
See related: AllianceGenome:WB:WBGene00013317
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase C binding activity. Predicted to be involved in several processes, including dendritic spine maintenance; positive regulation of receptor internalization; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in several cellular components, including cytoskeleton; perinuclear region of cytoplasm; and synapse. Predicted to be active in several cellular components, including cytoplasmic vesicle; postsynaptic density; and trans-Golgi network membrane. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y57G11C.22 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (14837211..14853667)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS4-204 (e-PCR)
- UniSTS:242196

Y57G11C.22 (e-PCR)
- UniSTS:322432

Y57G11C.19 (e-PCR)
- UniSTS:308191

Y57G11C.20 (e-PCR)
- UniSTS:308192

Y57G11C.21 (e-PCR)
- UniSTS:313572

F54H12.4 (e-PCR)
- UniSTS:311801

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dendritic spine maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PRKCA-binding protein

NP_001041046.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14837211..14853667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047581.4 → NP_001041046.1 PRKCA-binding protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041046.1

Status: REVIEWED

UniProtKB/TrEMBL

O18246

Conserved Domains (2) summary

cd07659
Location:142 → 356

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

cd00992
Location:39 → 97

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...