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    pho-8 intestinal acid PHOsphatase [ Caenorhabditis elegans ]

    Gene ID: 179621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pho-8
    Official Full Name
    intestinal acid PHOsphatase
    Primary source
    WormBase:WBGene00011262
    Locus tag
    CELE_R13H4.3
    See related
    AllianceGenome:WB:WBGene00011262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatase activity. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP2 (acid phosphatase 2, lysosomal) and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pho-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (11833619..11835708)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ABC1 atypical kinase-like domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Intrinsically Disordered Protein, class B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans. Guédon R, et al. Ecotoxicol Environ Saf, 2021 Dec 1. PMID 34544019
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intestinal acid PHOsphatase
    NP_505983.2
    • Product from WormBase gene class pho;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11833619..11835708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073582.5 → NP_505983.2  intestinal acid PHOsphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505983.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90949
      Conserved Domains (1) summary
      cd07061
      Location:21 → 327
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version

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