U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nas-7 Zinc metalloproteinase nas-7 [ Caenorhabditis elegans ]

    Gene ID: 182368, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nas-7
    Official Full Name
    Zinc metalloproteinase nas-7
    Primary source
    WormBase:WBGene00003526
    Locus tag
    CELE_C07D10.4
    See related
    AllianceGenome:WB:WBGene00003526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in nematode pharyngeal pumping and pharynx development. Predicted to be located in extracellular region. Is expressed in several structures, including arcade cell; hypodermis; pharynx; spermatheca; and vulva. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nas-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (7400545..7402725, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene BTB domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Serpentine receptor class delta-55 Neighboring gene Uncharacterized protein Neighboring gene Amino acid permease;Potassium/chloride cotransporter 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
    2. Improvement of Locomotion Caused by Lactococcus lactis subsp. lactis in the Model Organism Caenorhabditis elegans. Ali MS, et al. Nutrients, 2023 Oct 23. PMID 37892557, Free PMC Article
    3. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pharynx development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Zinc metalloproteinase nas-7
    NP_495552.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7400545..7402725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063151.4 → NP_495552.2  Zinc metalloproteinase nas-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495552.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55113, Q7Z0N5
      Conserved Domains (3) summary
      cd04280
      Location:91 → 270
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:87 → 274
      Astacin; Astacin (Peptidase family M12A)
      pfam01549
      Location:347 → 382
      ShK; ShK domain-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55113.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools