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    snx-27 Sorting nexin-27 [ Caenorhabditis elegans ]

    Gene ID: 172937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx-27
    Official Full Name
    Sorting nexin-27
    Primary source
    WormBase:WBGene00009116
    Locus tag
    CELE_F25H2.2
    See related
    AllianceGenome:WB:WBGene00009116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snx-27 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (10543024..10546429)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene CUE domain-containing protein Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene MPN domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility. Armada G, et al. Neurobiol Stress, 2024 May. PMID 38500791, Free PMC Article
    2. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking. Tian Y, et al. PLoS Genet, 2021 Jun. PMID 34081703, Free PMC Article
    3. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
    4. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
    5. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sorting nexin-27
    NP_492758.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10543024..10546429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060357.6 → NP_492758.1  Sorting nexin-27 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93566
      Conserved Domains (4) summary
      cd06886
      Location:166 → 271
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd00992
      Location:47 → 139
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:427 → 535
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
      cl00155
      Location:276 → 348
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version

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