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    fbp-1 fructose-bisphosphatase [ Caenorhabditis elegans ]

    Gene ID: 266822, updated on 9-Dec-2024

    Summary

    Official Symbol
    fbp-1
    Official Full Name
    fructose-bisphosphatase
    Primary source
    WormBase:WBGene00001404
    Locus tag
    CELE_K07A3.1
    See related
    AllianceGenome:WB:WBGene00001404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in anal depressor muscle; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See fbp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (2581015..2586124, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Amino Acid Transporter Neighboring gene SSD domain-containing protein Neighboring gene ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fructose-bisphosphatase
    NP_491004.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2581015..2586124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058603.8NP_491004.1  fructose-bisphosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491004.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBJ7
      Conserved Domains (1) summary
      cd00354
      Location:22336
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RNA

    1. NR_131360.1 RNA Sequence

      Status: REVIEWED