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    D2045.5 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 183952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D2045.5
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00008423
    Locus tag
    CELE_D2045.5
    See related
    AllianceGenome:WB:WBGene00008423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK1 (tau tubulin kinase 1) and TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See D2045.5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (10468058..10469624, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Proteasome component Ecm29 N-terminal domain-containing protein Neighboring gene Ataxin-2 homolog;Sm domain-containing protein Neighboring gene Cullin-1 Neighboring gene Glycosyltransferase 25 family member

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_499308.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10468058..10469624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066907.3 → NP_499308.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18984
      Conserved Domains (1) summary
      cd14017
      Location:16 → 277
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase
    Nucleotide Protein
    Heading Accession and Version

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