ocr-4 Ion transport domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ocr-4
Official Full Name: Ion transport domain-containing protein
Primary source: WormBase:WBGene00003841
Locus tag: CELE_Y40C5A.2
See related: AllianceGenome:WB:WBGene00003841
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in OLQDL; OLQDR; OLQVL; OLQVR; and uv1. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ocr-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (7329611..7332795, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel.
Title: Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y40C5A.e (e-PCR)
- UniSTS:322839

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Ion transport domain-containing protein

NP_501172.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7329611..7332795 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068771.8 → NP_501172.2 Ion transport domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501172.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9N3Y9

Conserved Domains (2) summary

TIGR00870
Location:105 → 668

trp; transient-receptor-potential calcium channel protein

sd00045
Location:154 → 194

ANK; ANK repeat [structural motif]