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    sulp-5 STAS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sulp-5
    Official Full Name
    STAS domain-containing protein
    Primary source
    WormBase:WBGene00010789
    Locus tag
    CELE_K12G11.2
    See related
    AllianceGenome:WB:WBGene00010789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Located in apical plasma membrane. Is expressed in excretory cell and seam cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61; calcium oxalate nephrolithiasis; and spermatogenic failure 3. Orthologous to several human genes including SLC26A5 (solute carrier family 26 member 5) and SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sulp-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (11880032..11883219)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Alcohol dehydrogenase 1 Neighboring gene Alcohol dehydrogenase 2 Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
    2. Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway. Wong C, et al. PLoS Genet, 2023 Apr. PMID 37058536, Free PMC Article
    3. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Armstrong KR, et al. Mol Genet Genomics, 2010 Jan. PMID 19921263
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STAS domain-containing protein
    NP_505990.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11880032..11883219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073589.5 → NP_505990.3  STAS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17951, Q58QG3
      Conserved Domains (2) summary
      cd07042
      Location:549 → 699
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:101 → 498
      Sulfate_transp; Sulfate permease family
    Nucleotide Protein
    Heading Accession and Version

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